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The Observatory reported heavy fighting on several fronts.
The Syrian Observatory for Human Rights, a war monitoring group in Britain, says 915 civilians have died in the last 18 days, including 91 on Wednesday. They had an estimated population of about 50,000 in December, the official said.
The pro-Damascus commander, who spoke on condition of anonymity because he was not authorised to talk to the media, confirmed a report by the Observatory late on Wednesday that the enclave had effectively been sliced in two.
But Wael Alwan, the Istanbul-based spokesman for Failaq al-Rahman, one of the main rebel groups in eastern Ghouta, denied that the territory had been cut in half.
Local rescue workers said gas had affected 50 people.
Social media activists shared videos and photos, which Reuters could not verify, of people with signs of breathing difficulties.