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The virus injection procedure will be completed within 6.5 hrs.The catheter will be removed following the post-PVSRIPO infusion MRI.
Drug infusion will occur in the NSICU or neuro step down unit so that all other emergency facilities will be available.
Purpose of the Study: To determine the maximally tolerated dose (MTD) or the Phase II dose of PVSRIPO when delivered intracerebrally by convection-enhanced delivery (CED).
To estimate the efficacy of PVSRIPO administered at the optimal dose.
PVSRIPO is a genetically recombinant, non-pathogenic poliovirus:rhinovirus chimera with a tumor-specific conditional replication phenotype.
It consists of the genome of the live attenuated poliovirus serotype 1 (SABIN) vaccine (PV1S) with its cognate internal ribosomal entry site (IRES) element replaced with that of human rhinovirus type 2 (HRV2).
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