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She studied musical theatre at the Arts Educational Schools, London, and made her stage breakthrough with a leading role in a 1987 production of 42nd Street.Her screen debut came in the unsuccessful French-Italian film 1001 Nights (1990), and she went on to find greater success as a regular in the British television series The Darling Buds of May (1991–1993).Critics praised her portrayal of a vengeful pregnant woman in Traffic (2000) and a murderous singer in the musical Chicago (2002).The latter won her Academy and BAFTA Awards for Best Supporting Actress, among other accolades.
Her struggle with depression and bipolar II disorder has been well documented by the media.
Dismayed at being typecast as the token pretty girl in British films, Zeta-Jones relocated to Los Angeles.
Zeta-Jones initially established herself in Hollywood with roles that highlighted her sex appeal such as in the action film The Mask of Zorro (1998) and the heist film Entrapment (1999).
Describing her teenage years in London, Zeta-Jones said, "I would queue up for auditions and then change my costume or put on a different leotard and audition again.
It might take me two tries, but I always got the job. In 1987, when she was 17 years old, Zeta-Jones was picked as the second understudy to the lead actress in a West End production of 42nd Street.
Campbell cast her as the leading lady in favour of Izabella Scorupco, who was his original choice for the part.